Raynaud-like phenomenon in two patients on nilotinib

Raynaud ’ s Phenomenon

terized by one or more fingers becoming blanched, cyanotic, and red (often in that order), upon an individual’s exposure to cold stimuli or emotional stress.1 These color changes are attributable to several factors; however, they mainly result from vasospasms of the digital arteries. The disorder occurs fairly commonly and can have a variety of other presentations, ranging from mild discomfort ...

Smoker with Raynaud phenomenon and painful nodules on the legs.

Treating Raynaud phenomenon: Beyond staying warm.

Raynaud phenomenon is an overactive vascular response to cold and emotional stress that results in cutaneous color changes and sensory symptoms in the digits. It can be idiopathic (primary) or secondary to another condition; the latter can be more severe and more apt to lead to ischemic complications such as digital ulceration and even loss of digits. If nonpharmacologic interventions prove ina...

Laser speckle contrast imaging of Raynaud phenomenon.

483 peripheral microcirculatory blood flow on a large area of the body.1 LSCI is user‐friendly and shows very good reproducibility as well as excellent spa‐ tial and temporal resolutions.2 In clinical studies, LSCI coupled with reactivity tests enable to esti‐ mate the endothelial and neurovascular function. We present the measurements of skin per‐ fusion assessed by LSCI in patients with pri‐ ...

Finger pad tophi in a patient with Raynaud phenomenon

MSU: monosodium urate ULT: urate-lowering therapy INTRODUCTION The natural history of gout includes 4 progressive stages (asymptomatic hyperuricemia, acute arthritic attacks, intercritical gout, and chronic gouty arthritis). Asymptomatic hyperuricemia is characterized by elevated serum urate. Deposition of monosodium urate (MSU) crystals in articular and periarticular tissues then instigates ac...